Palmitoyl ethanolamide (PEA) is an endogenous cannabinoid found in brain, liver, and other mammalian tissues. At the base of the analgesic, anti-inflammatory, or antioxidant action of Regulatory Status: RUO - Research Use Only Objective: To assess the tolerability profile of several commercial topical formulations containing cannabidiol (CBD) and palmitoylethanolamide (PEA) on the skin of Palmitoylethanolamide is a weak ligand of the cannabinoid 1 (CB1) and cannabinoid 2 (CB2) receptors. Those taking Palmitoylethanolamide supplements are advised to take 350-400 mg thrice a day and the dosage duration should not exceed 2 months in total.
Research has found that COX-2 levels are elevated during periods of pain and inflammation. Levagen+ Palmitoylethanolamide VeriSperse Resveratrol CapsulesNew. Palmitoylethanolamide (PEA) is an endocannabinoid-like lipid mediator with extensively documented anti-inflammatory, analgesic, antimicrobial, immunomodulatory and neuroprotective effects. It is a colorless waxy solid and occurs in nature. Palmitoylethanolamide, or PEA, is a compound which has analgesic, anti-inflammatory and neuroprotective effects. Already in the 1970s a number of RCTs were published, supporting the efficacy and safety of PEA in the treatment and the prophylaxis of flu and common cold. In the workd market,there are four main dosage formulations of palmitoylethanolamide : .capsules .soft gels .tablet .cream Palmitoylethanolamide food sources Shipping Condition The tissue distribution of PEA has also been studied: Grillo et al. send inquiry CBD vs Palmitoylethanolamide Palmitoylethanolamide (PEA, N-(2-hydroxyethyl) hexadecamide, palmidrol; struct ure shown in Figure 1) belongs to the fa mily of N -acylethanolamine s (NAEs), endogeno us On-Demand Delivery of Single DNA Molecules Using Nanopipets; Regioselective Synthesis of 1-Bromo-1,4-dienes by Free-Radical-Mediated Bromoallylation of Activated Acetylenes "Study of the regulation of the endocannabinoid system in a virus model of multiple sclerosis reveals a therapeutic effect of palmitoylethanolamide". The European Journal of Neuroscience. 28 (4): 63341. doi: 10.1111/j.1460-9568.2008.06377.x. hdl: 10261/73342. PMID 18657182. S2CID 11299981. Modulates mast cell activation. Palmitoylethanolamide in MS. PEA has been extensively explored in a great number of inflammatory animal models, as well as in many clinical trials. Sometimes labeled as a fatty acid primary amide (FAPA), it is Micronized for improved solubility and absorption. Palmitoylethanolamide is practically insoluble in water and poorly soluble in most other aqueous solvents. Modulates mast cell activation. 9-THC has a large apparent volume of distribution, approximately 10 L/kg, because of its high lipid solubility Reference 446. [4] It is the amide derived from the fatty acid oleic acid. Palmitoylethanolamide (PEA) is a relevant anti-inflammatory and neuroprotective drug whose poor solubility is currently addressed by micronization with traditional fluid technology. CAS No.
Either preclinical or clinical studies indicate that PEA is potentially useful in a wide range of therapeutic areas, including eczema, pain, and neurodegeneration. Krill Oil Gelcaps. CBN has an even higher volume of distribution, 50 L/kg Reference 447. Solubility and gelation. Oleamide is an organic compound with the formula CH 3 (CH 2) 7 CH=CH (CH 2) 7 CONH 2 (. Cannabis tea is made by first adding a saturated fat to hot water (e.g. During the SEE process, particles are formed as a consequence of the extraction of the organic solvent of an oil in water (o/w) emulsion. It has been found that Palmitoylethanolamide can inhibit fatty acid amide hydrolase. National Library of Medicine. Palmitoylethanolamide ( PEA) is an endogenous fatty acid amide, and lipid modulator [2] PEA has been studied in in vitro and in vivo systems using exogenously added or dosed compound; there is evidence that it binds to a nuclear receptor, [3] through which it exerts a variety of biological effects, some related to chronic inflammation and pain. Different formulations have been made to enhance absorption. tert-Pentanol and 1-hexanol could also dissolve high-viscosity PAO-150. As of 2019, clinical research on CBD included studies related to anxiety, cognition, movement disorders, and pain, but there is insufficient high-quality evidence that PEA is able to form gels in alkanes (hexane, cyclohexane, trans-decalin and in several edible oils for wt. Ultramicronized Palmitoylethanolamide (um-PEA) is well-known for its ability to promote the resolution of neuroinflammation and exert neuroprotection. Solubility :soluble and dispersible in cold water and hot water Dispersible PEA specification on the market is 90%, while cima have a min spec of 97%. It is found in soybeans, egg yolk, and many other food sources. In order to further optimize OptiPEA we also make sure that there is a good particle dispersion and fineness to the powder. The empirical solubility of hydrocarbon fluids, polyalphaolefin (PAO) and mineral oil, in thirteen small molecular weight alcohols (C1C6) was determined. Palmitoylethanolamide (PEA) is synthesized by healthy tissue in the human body in response to inflammation [ 1 ]. Questions? 1 PEA has also been isolated from egg yolk, and found to have anti- anaphylactic and anti- inflammatory activity in vitro. Taken in doses of 500mg-1.5g per dosage, every few hours, PEA provides the user a feeling of euphoria, energy, stimulation, and overall well being. A Closer Look at the Mechanisms of Action of PEA ( for those really interested) N-oleoylethanolamine and N-palmitoylethanolamine (PEA or palmitoylethanolamide). 9: highest resistance, no change. The International Association for the Study of Pain (IASP) describes pain as an unpleasant sensory and emotional experience that is associated with real or probable tissue damage, as defined in rapports of such injury [].Although it is easy to conceptualize pain as a homogeneous entity, in reality there are several different types, each with distinct Interestingly, the expression of these proinflammatory molecules was also discovered in cases of neuroinflammation. Is Palmitoylethanolamide (PEA) safe? Though Palmitoylethanolamide is well-tolerated by the body, in case people notice any side-effects, they are advised to reduce the dosage amount to 400 mg a day. More importantly, the compound should not be taken for more than three months. The dialk It is a weak ligand of the cannabinoid 1 (CB1) and cannabinoid 2 (CB2) receptors, it has been found to inhibits fatty acid amide hydrolase (FAAH) ( (IC50 = 5.1 M). This result may be attributed to the fact that FFAs in the waste oil were mainly long chain palmitic and oleic acids having low solubility in the methanol ( Palmitoylethanolamide (PEA, Palmidrol, N-palmitoylethanolamine) is an endogenous fatty acid amide and selectively activates PPAR- in vitro with an EC50 value of 3.10.4 M. Solubility: DMF: 10 mg/ml,DMSO: 5 mg/ml,Ethanol: 2 mg/ml,Ethanol:PBS (pH 7.2)(:10): .01 mg/ml Storage: Store at RT General tips: For obtaining a higher solubility , please warm the tube at 37 and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 for several months.
Article by: Dr. Zeng. 1. Stock solutions are stable for up to 3 months at -20C. Palmitoylethanolamide (Palmidrol) is an active endogenous compound which can used for preventing virus infection of the respiratory tract. 2 PEA is an endocannabinoid which has been shown to significantly elevate cAMP in cells expressing CB 2 receptors. [2] It works as a signaling molecule to down-regulate the inflammatory response of glial cells and mast cells. The choice of healthy sources of carbohydrates, fats, and proteins, associated with regular physical activity and avoidance of smoking is essential to fight the war against chronic diseases. 1.25 g of ethanolamine was added and the resulting oily mixture warmed at 120C in an oil bath for 4 h under a nitrogen atmosphere. Palmitoylethanolamide is a nutraceutical compound naturally produced in many plants and animal source foods, but the natural form is poorly water-soluble. During a study that was conducted in 1950, some researchers found that patients, in that case less privileged children, which were subjected to a diet rich of dry chicken and egg yolk did not contract rheumatic fever. Butanols, pentanols, and 1-hexanol could dissolve up to PAO-10 and mineral oil. Introduction. In addition, Liposomal PalmitoylethanolamidePalmitoylethanolamide-Oxazoline (PEA-OXA) are also available upon your request. kg 1 ), the highest plasma concentration was achieved after 15 min corresponding to a 20fold increase in its basal values. About. Cannabidiol (CBD) is a phytocannabinoid discovered in 1940. cream or any milk except skim) with a Palmitoylethanolamide (PEA, N(2hydroxyethyl) hexadecamide, palmidrol; structure shown in Figure1) belongs to the family of Nacylethanolamines (NAEs), endogenous biologically active lipids including the endogenous cannabinoid receptor ligand anandamide and the satiety factor oleoylethanolamide. BioClinical Nautral's Natural Source PEA is a Fraction of Non-GMO Safflower Oil. Weak ligand for CB 1 (K i = 23.8 M) and CB 2 (K i = 13.9 M) receptors. N- (2-hydroxyethyl)-exadecanamide, commonly known as palmitoylethanolamide (PEA), belongs to the N- acylethanolamine family (NAE). Therapeutic E cacy of Palmitoylethanolamide and Its New Formulations in Synergy with Di erent Antioxidant Molecules Present in Diets Alessio Filippo Peritore 1,y, supplementation of DHA-rich sh oil (FO) as compared with the diet supplemented with low n-3 PUFA. PEA (palmitoylethanolamide) is a fatty-acid-like compound which is a fraction of non-GMO safflower oil. Shipping: Ambient : Long Term Storage: +4C : Use/Stability: Stable for at least 1 year after receipt when stored, as supplied, at 0-4C. 1. Inhibits fatty acid amide hydrolase (FAAH) ((IC 50 = 5.1 M). National Institutes of Health. 30 reported that in a small sample ( n = 34 per group), administration of PEA (10 mg kg 1) emulsified in corn oil increased levels of this lipid in the heart and brain of DBA/2 mice 24 and/or 48 h Palmitoylethanolamide (PEA, N -hexadecanoylethanolamide) is an endogenous compound belonging to the family of N -acylethanolamines. Palmitoylethanolamide (PEA) is a natural fatty acid amide of ethanolamine and palmitic acid. Palmitoylethanolamide may also help regulate the expression of cyclooxygenase-2 (COX-2) as well as inducible nitric oxide synthase (iNOS). Cannabis tea, which contains relatively small concentrations of THC because THC is an oil and is only slightly water-soluble (with a solubility of 2.8 mg per liter). 1: decomposition. So that palmitic acid is an abundant raw material that can be used in various fields of oleo chemical industry. The crystallization of OptiPEA during one of the final production steps enhances its biological and product technical features.
. PEA has anti-inflammatory and analgesic properties and is very well tolerated in humans. component of oil from palm trees, which is the first fatty acid produced in the process of lipogenesis in the form of carboxylic acids with long and unbranched tails [3]. PEA is found in a number of common foods, including cows milk, breast milk, beans, peas, tomatoes, alfalfa, corn, soy lecithin and peanuts. 2: severe distortion; oxidizer and plasticizer deteriorated. It is well tolerated and devoid of side effects in animals and humans. What is it? Popular Products. N-Palmitoylethanolamide (PEA) is a non-endocannabinoid lipid mediator belonging to the class of the N-acylethanolamine phospolipids and was firstly isolated from soy lecithin, egg yolk, and peanut meal. Introduction: While an increasing number of studies have investigated the side effect profile of oral cannabinoids, few studies have provided sufficient data on the tolerability of topical cannabinoids in human subjects.
It is a peroxisome proliferator-activated receptor (PPAR-) ligand. In the present article, the basal pharmacology of PEA is reviewed. It is soluble in water but insoluble in oil. Substance record SID 24278619 for Palmitoylethanolamide submitted by Sigma-Aldrich. Chat, Email Email [emailprotected] or Call 800-654-4432 or Call 800-654-4432. Palmitoylethanolamide (Palmidrol) itself does not stimulate interferon production in mice treated per os or intravenously. The search for a new and efficient chemical Palmitoylethanolamide exhibits anti-nociceptive, anti-inflammatory, anti-convulsant and immunosuppresant activity. The solvents used depend on the solubility of the active compounds in The mixture was then cooled to room temperature and partitioned using ethyl acetate and water. The resulting solution was refluxed under a dry nitrogen atmosphere for 2 h and then evaporated under vacuum. It is one of 113 identified cannabinoids in cannabis plants, along with tetrahydrocannabinol (THC), and accounts for up to 40% of the plant's extract. PubChem. The apparent average volume of distribution of CBD is 32.7 L/kg (higher than THC) owing also to its very high lipid solubility Reference 410. fraction of 0.5%. The use of a complete nutritional approach seems increasingly promising to combat chronic inflammation. This study was designed to assess the efficacy of um-PEA as adjuvant therapy in patients with advanced PD. PEA is an endogenous cannabinoid receptor agonist. It has demonstrated an anti-inflammatory role as a neuroprotective mediator, acting on several molecular targets of the central nervous system involved on brain aging process.
Research has found that COX-2 levels are elevated during periods of pain and inflammation. Levagen+ Palmitoylethanolamide VeriSperse Resveratrol CapsulesNew. Palmitoylethanolamide (PEA) is an endocannabinoid-like lipid mediator with extensively documented anti-inflammatory, analgesic, antimicrobial, immunomodulatory and neuroprotective effects. It is a colorless waxy solid and occurs in nature. Palmitoylethanolamide, or PEA, is a compound which has analgesic, anti-inflammatory and neuroprotective effects. Already in the 1970s a number of RCTs were published, supporting the efficacy and safety of PEA in the treatment and the prophylaxis of flu and common cold. In the workd market,there are four main dosage formulations of palmitoylethanolamide : .capsules .soft gels .tablet .cream Palmitoylethanolamide food sources Shipping Condition The tissue distribution of PEA has also been studied: Grillo et al. send inquiry CBD vs Palmitoylethanolamide Palmitoylethanolamide (PEA, N-(2-hydroxyethyl) hexadecamide, palmidrol; struct ure shown in Figure 1) belongs to the fa mily of N -acylethanolamine s (NAEs), endogeno us On-Demand Delivery of Single DNA Molecules Using Nanopipets; Regioselective Synthesis of 1-Bromo-1,4-dienes by Free-Radical-Mediated Bromoallylation of Activated Acetylenes "Study of the regulation of the endocannabinoid system in a virus model of multiple sclerosis reveals a therapeutic effect of palmitoylethanolamide". The European Journal of Neuroscience. 28 (4): 63341. doi: 10.1111/j.1460-9568.2008.06377.x. hdl: 10261/73342. PMID 18657182. S2CID 11299981. Modulates mast cell activation. Palmitoylethanolamide in MS. PEA has been extensively explored in a great number of inflammatory animal models, as well as in many clinical trials. Sometimes labeled as a fatty acid primary amide (FAPA), it is Micronized for improved solubility and absorption. Palmitoylethanolamide is practically insoluble in water and poorly soluble in most other aqueous solvents. Modulates mast cell activation. 9-THC has a large apparent volume of distribution, approximately 10 L/kg, because of its high lipid solubility Reference 446. [4] It is the amide derived from the fatty acid oleic acid. Palmitoylethanolamide (PEA) is a relevant anti-inflammatory and neuroprotective drug whose poor solubility is currently addressed by micronization with traditional fluid technology. CAS No.
Either preclinical or clinical studies indicate that PEA is potentially useful in a wide range of therapeutic areas, including eczema, pain, and neurodegeneration. Krill Oil Gelcaps. CBN has an even higher volume of distribution, 50 L/kg Reference 447. Solubility and gelation. Oleamide is an organic compound with the formula CH 3 (CH 2) 7 CH=CH (CH 2) 7 CONH 2 (. Cannabis tea is made by first adding a saturated fat to hot water (e.g. During the SEE process, particles are formed as a consequence of the extraction of the organic solvent of an oil in water (o/w) emulsion. It has been found that Palmitoylethanolamide can inhibit fatty acid amide hydrolase. National Library of Medicine. Palmitoylethanolamide ( PEA) is an endogenous fatty acid amide, and lipid modulator [2] PEA has been studied in in vitro and in vivo systems using exogenously added or dosed compound; there is evidence that it binds to a nuclear receptor, [3] through which it exerts a variety of biological effects, some related to chronic inflammation and pain. Different formulations have been made to enhance absorption. tert-Pentanol and 1-hexanol could also dissolve high-viscosity PAO-150. As of 2019, clinical research on CBD included studies related to anxiety, cognition, movement disorders, and pain, but there is insufficient high-quality evidence that PEA is able to form gels in alkanes (hexane, cyclohexane, trans-decalin and in several edible oils for wt. Ultramicronized Palmitoylethanolamide (um-PEA) is well-known for its ability to promote the resolution of neuroinflammation and exert neuroprotection. Solubility :soluble and dispersible in cold water and hot water Dispersible PEA specification on the market is 90%, while cima have a min spec of 97%. It is found in soybeans, egg yolk, and many other food sources. In order to further optimize OptiPEA we also make sure that there is a good particle dispersion and fineness to the powder. The empirical solubility of hydrocarbon fluids, polyalphaolefin (PAO) and mineral oil, in thirteen small molecular weight alcohols (C1C6) was determined. Palmitoylethanolamide (PEA) is synthesized by healthy tissue in the human body in response to inflammation [ 1 ]. Questions? 1 PEA has also been isolated from egg yolk, and found to have anti- anaphylactic and anti- inflammatory activity in vitro. Taken in doses of 500mg-1.5g per dosage, every few hours, PEA provides the user a feeling of euphoria, energy, stimulation, and overall well being. A Closer Look at the Mechanisms of Action of PEA ( for those really interested) N-oleoylethanolamine and N-palmitoylethanolamine (PEA or palmitoylethanolamide). 9: highest resistance, no change. The International Association for the Study of Pain (IASP) describes pain as an unpleasant sensory and emotional experience that is associated with real or probable tissue damage, as defined in rapports of such injury [].Although it is easy to conceptualize pain as a homogeneous entity, in reality there are several different types, each with distinct Interestingly, the expression of these proinflammatory molecules was also discovered in cases of neuroinflammation. Is Palmitoylethanolamide (PEA) safe? Though Palmitoylethanolamide is well-tolerated by the body, in case people notice any side-effects, they are advised to reduce the dosage amount to 400 mg a day. More importantly, the compound should not be taken for more than three months. The dialk It is a weak ligand of the cannabinoid 1 (CB1) and cannabinoid 2 (CB2) receptors, it has been found to inhibits fatty acid amide hydrolase (FAAH) ( (IC50 = 5.1 M). This result may be attributed to the fact that FFAs in the waste oil were mainly long chain palmitic and oleic acids having low solubility in the methanol ( Palmitoylethanolamide (PEA, Palmidrol, N-palmitoylethanolamine) is an endogenous fatty acid amide and selectively activates PPAR- in vitro with an EC50 value of 3.10.4 M. Solubility: DMF: 10 mg/ml,DMSO: 5 mg/ml,Ethanol: 2 mg/ml,Ethanol:PBS (pH 7.2)(:10): .01 mg/ml Storage: Store at RT General tips: For obtaining a higher solubility , please warm the tube at 37 and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 for several months.
Article by: Dr. Zeng. 1. Stock solutions are stable for up to 3 months at -20C. Palmitoylethanolamide (Palmidrol) is an active endogenous compound which can used for preventing virus infection of the respiratory tract. 2 PEA is an endocannabinoid which has been shown to significantly elevate cAMP in cells expressing CB 2 receptors. [2] It works as a signaling molecule to down-regulate the inflammatory response of glial cells and mast cells. The choice of healthy sources of carbohydrates, fats, and proteins, associated with regular physical activity and avoidance of smoking is essential to fight the war against chronic diseases. 1.25 g of ethanolamine was added and the resulting oily mixture warmed at 120C in an oil bath for 4 h under a nitrogen atmosphere. Palmitoylethanolamide is a nutraceutical compound naturally produced in many plants and animal source foods, but the natural form is poorly water-soluble. During a study that was conducted in 1950, some researchers found that patients, in that case less privileged children, which were subjected to a diet rich of dry chicken and egg yolk did not contract rheumatic fever. Butanols, pentanols, and 1-hexanol could dissolve up to PAO-10 and mineral oil. Introduction. In addition, Liposomal PalmitoylethanolamidePalmitoylethanolamide-Oxazoline (PEA-OXA) are also available upon your request. kg 1 ), the highest plasma concentration was achieved after 15 min corresponding to a 20fold increase in its basal values. About. Cannabidiol (CBD) is a phytocannabinoid discovered in 1940. cream or any milk except skim) with a Palmitoylethanolamide (PEA, N(2hydroxyethyl) hexadecamide, palmidrol; structure shown in Figure1) belongs to the family of Nacylethanolamines (NAEs), endogenous biologically active lipids including the endogenous cannabinoid receptor ligand anandamide and the satiety factor oleoylethanolamide. BioClinical Nautral's Natural Source PEA is a Fraction of Non-GMO Safflower Oil. Weak ligand for CB 1 (K i = 23.8 M) and CB 2 (K i = 13.9 M) receptors. N- (2-hydroxyethyl)-exadecanamide, commonly known as palmitoylethanolamide (PEA), belongs to the N- acylethanolamine family (NAE). Therapeutic E cacy of Palmitoylethanolamide and Its New Formulations in Synergy with Di erent Antioxidant Molecules Present in Diets Alessio Filippo Peritore 1,y, supplementation of DHA-rich sh oil (FO) as compared with the diet supplemented with low n-3 PUFA. PEA (palmitoylethanolamide) is a fatty-acid-like compound which is a fraction of non-GMO safflower oil. Shipping: Ambient : Long Term Storage: +4C : Use/Stability: Stable for at least 1 year after receipt when stored, as supplied, at 0-4C. 1. Inhibits fatty acid amide hydrolase (FAAH) ((IC 50 = 5.1 M). National Institutes of Health. 30 reported that in a small sample ( n = 34 per group), administration of PEA (10 mg kg 1) emulsified in corn oil increased levels of this lipid in the heart and brain of DBA/2 mice 24 and/or 48 h Palmitoylethanolamide (PEA, N -hexadecanoylethanolamide) is an endogenous compound belonging to the family of N -acylethanolamines. Palmitoylethanolamide (PEA) is a natural fatty acid amide of ethanolamine and palmitic acid. Palmitoylethanolamide may also help regulate the expression of cyclooxygenase-2 (COX-2) as well as inducible nitric oxide synthase (iNOS). Cannabis tea, which contains relatively small concentrations of THC because THC is an oil and is only slightly water-soluble (with a solubility of 2.8 mg per liter). 1: decomposition. So that palmitic acid is an abundant raw material that can be used in various fields of oleo chemical industry. The crystallization of OptiPEA during one of the final production steps enhances its biological and product technical features.
. PEA has anti-inflammatory and analgesic properties and is very well tolerated in humans. component of oil from palm trees, which is the first fatty acid produced in the process of lipogenesis in the form of carboxylic acids with long and unbranched tails [3]. PEA is found in a number of common foods, including cows milk, breast milk, beans, peas, tomatoes, alfalfa, corn, soy lecithin and peanuts. 2: severe distortion; oxidizer and plasticizer deteriorated. It is well tolerated and devoid of side effects in animals and humans. What is it? Popular Products. N-Palmitoylethanolamide (PEA) is a non-endocannabinoid lipid mediator belonging to the class of the N-acylethanolamine phospolipids and was firstly isolated from soy lecithin, egg yolk, and peanut meal. Introduction: While an increasing number of studies have investigated the side effect profile of oral cannabinoids, few studies have provided sufficient data on the tolerability of topical cannabinoids in human subjects.
It is a peroxisome proliferator-activated receptor (PPAR-) ligand. In the present article, the basal pharmacology of PEA is reviewed. It is soluble in water but insoluble in oil. Substance record SID 24278619 for Palmitoylethanolamide submitted by Sigma-Aldrich. Chat, Email Email [emailprotected] or Call 800-654-4432 or Call 800-654-4432. Palmitoylethanolamide (Palmidrol) itself does not stimulate interferon production in mice treated per os or intravenously. The search for a new and efficient chemical Palmitoylethanolamide exhibits anti-nociceptive, anti-inflammatory, anti-convulsant and immunosuppresant activity. The solvents used depend on the solubility of the active compounds in The mixture was then cooled to room temperature and partitioned using ethyl acetate and water. The resulting solution was refluxed under a dry nitrogen atmosphere for 2 h and then evaporated under vacuum. It is one of 113 identified cannabinoids in cannabis plants, along with tetrahydrocannabinol (THC), and accounts for up to 40% of the plant's extract. PubChem. The apparent average volume of distribution of CBD is 32.7 L/kg (higher than THC) owing also to its very high lipid solubility Reference 410. fraction of 0.5%. The use of a complete nutritional approach seems increasingly promising to combat chronic inflammation. This study was designed to assess the efficacy of um-PEA as adjuvant therapy in patients with advanced PD. PEA is an endogenous cannabinoid receptor agonist. It has demonstrated an anti-inflammatory role as a neuroprotective mediator, acting on several molecular targets of the central nervous system involved on brain aging process.