20160059) approved by the Animal Care Committee at the University of Saskatchewan, following guidelines of the Canadian Council on Animal Care and the ARRIVE guidelines (Reference Kilkenny, Browne and Cuthill 25). *New* Immunocompromised SRG Rat The SRG rat is highly immunodeficient - lacking mature B, T, and NK cells. Dose Adjustment Factor (DAF): 0.26 (Body weight scaling, Chronic Sprague Dawley female rat) (USEPA, 2011) (MDH, 2017) Human Equivalent Dose (HED): POD x DAF = 0.259 mg/kg-d x 0.26 = 0.067 mg/kg-d . In male Sprague-Dawley rats, the total body weight appeared to be significantly (p<0.05) lower in groups B (19.750.75g), C (22.500.50g) and D (15.331.21g) when compared to the control group (29.002.31g) (Figure 1). . Toxicol. C, table showing plasma and tissue concentrations at 2 h after administration of 10 mg/kg i.p. Transferred to Harlan Sprague-Dawley, Inc. in 1993 (nomenclature HsdHan :WIST). Originated in 1925 by Robert W. Dawley from a hybrid hooded male and a female Wistar rat. No drug-related tumors were noted in this study up to the highest dose evaluated in this study of 30 mg/kg/day [3.6 Description Growth Chart Health Report Pricing CD (Sprague Dawley) IGS Rat Details Originated in 1925 by Robert W. Dawley from a hybrid hooded male and a female Wistar rat. The absolute of the weights of the brain, spleen, heart, lungs, liver, kidneys, adrenal glands and testes were increased in male SD rats from 13 to 78 weeks, and the weights of the brain, heart . five rats each using randomization chart. Low-D rats were fed a diet . Weight (grams) MODEL CODE 047 Characteristics Litter average: 6.0 Docile disposition dHaplotype: H-2 Experimental allergic encephalomyelitis resistant We hypothesized that differences in gut microbiota composition account for phenotype differences between obese prone (OP) and obese resistant (OR) rats. [(accessed on 31 May 2019)]; . 2. A main study starting dose of 5,000 mg/kg was the limit in the acute toxicity study. wt. Perinatal exposure to low levels of the fungal toxin deoxynivalenol (DON) leads to mild toxicity in male and female offspring of Sprague Dawley rats, according to a report published by Division of the National Toxicology Program (DNTP) researchers and collaborators. The first group (TBE) received 250 mg/kg of 2.5% solution of . Energy ingestion ( A) and body weight ( B) of Wistar and Sprague-Dawley (SD) rats fed either with standard (St) or high-fat (HF) diet along the 17 weeks of the study. Proper male adult sprague dawley rats has weight 220-230 grams. . Sprague-Dawley rats. A fast growing rat, it is docile and easy to handle. P < 0.05 between St and HF diet groups of both strains and P < 0.05 between St and HF diet groups of Wistar rats. You will be utilizing male rats for your experiments in this class, but both sexes are commonly used in research. The main advantage to Sprague Dawley rats is their calm demeanor, leading to ease of handling. Hum. Harlan became Envigo in 2015. Animal care. 0 . SAS Sprague Dawley Rat Breeding Location US Description Growth Chart Health Report Pricing SAS Sprague Dawley Rat Details To SASCO from ARS/Sprague Dawley in 1979. Effects of androgens on body weight and seminal vesicle weight. The rats are maintained as an outbred closed colony. Reproduction: Puberty : 6 - 8 weeks: Figure 5. Table 2. To Charles River in 1950 from Sprague Dawley, Inc. The average litter size of the Sprague Dawley rat is 10.5. An Weights Of Sprague Dawley Rats And Age Table. Environment Requirements: Room Temperature : 65-79F / 18-28C: Relative Humidity : 30% - 70 %: Housing Space : 40 in. per 300 gm. as well as monitoring clinical signs during daily health checks. Surgically decreased placental blood . Weight (female average adult) 225 - 400 gm: Nipples (found only on females) Average 6 pairs: Life span (average) 24 - 40 months . Body weight was analyzed using repeated measures ANOVA 3 (HgCl 2) 8 (length of exposure) factorial design, with duration of exposure as the repeated measure. jim crow vocabulary worksheet answer key . The typical life span is 2.5-3.5 years. Animal care. All vertebrate species yawn, but with low frequencies. Sprague-Dawley rats supplied by Harlan (HSD) and Charles River (CRSD) Laboratories; specically, CRSD rats appear to . Main application and research fields Cardiovascular diseases Degenerative diseases, ageeing Metabolic disorders Neurosciences Oncology Physiology - Physiopathology Preclinical The main advantage to Sprague Dawley rats is their calm demeanor, leading to ease of handling. Sprague-Dawley rats undergoing ovariectomy * Ajadi, R. Adetola 1,2, Gazal, . Birth weight (g) 0.5 - 1.5 3 - 5 900 - 1600 Weaning weight male/female (g) 18 - 25/16 - 25 55 - 90/45 - 80 6000 - 8000 Suckling period (days) Body weight and composition in the Sprague Dawley rat: comparison of three outbred sources Abstract Body weight with age and final composition for water, fat, and protein, were measured in three outbred stocks derived from the Sprague Dawley rat. Growth chart includes mean + 2 SD's representative of population distribution. Rederived into isolator foundation colony in 1997. . 2. The light cycle was 12-h light and 12-h darkness, with lights-off at 1900 h. Male Sprague Dawley Rats, supplied by Charles River Laboratories, used in various techniques. Therefore, our birth weight is approximately 3% of our adult weight. Figure 3 Adrenal gland, Cortex - Hypertrophy in a male B6C3F1/N/N mouse from a chronic study. Since our study involved examining several organ and plasma samples, human studies were not feasible. Intrathecal Compounds The SPRAGUE DAWLEY rat aka SD, is an albino outbred rat with an elongated head and a tail that is . Alendronate dose for human are converted to mice dose based on Hau and Hoosier's theory. The weight of male/female rat (Sprague-Dawley, Dark Agouti, and Lewis) is normally above 190/130 g after 9 weeks old (adulthood) . 2. .
Male C57BL6 mice, male Sprague-Dawley, Wistar rats most common. The effect measure is based on the reproductive organ weight, histology of testis, and sperm Rat strain and differences in high fat t induced obesity rat strain and differences in body weight g for sprague dawley hilltop lab animals inc hla wi. Intra-peritoneal injection of low doses (13.3 mg/Kg body weight) of aqueous extract Received: September 1, 2009 of Alligator pepper (Aframomum melegueta) Accepted: December 18, 2009 causes reduction in gestational weight gain in female Sprague dawley rats. This study was approved by the animal care and ethics committee of the Southern Medical University. BWs were significantly different between treatment groups at cross-over (P < 0.05), but were not significantly different . Posted on May 5, 2017 by Eva. Experimental groups and drugs administration. Reference values for young normal Sprague Dawley rats: Weight gain, hematology and clinical chemistry. High fat + cholesterol (~1%) and cholate (~0.5%) Equal to HFD lacking cholesterol and cholate. Arterial blood from 63 male (315-500 g) and 60 female (210-290 g) healthy Sprague-Dawley rats was analyzed for 16 hematological and 22 clinical chemistry parameters. In 1950, Charles River Laboratories (CRL) acquired a breeding stock and developed a new line with better microbial status by caesarian derivation [ 22 ]. : : : : 3: 485.7: 383.0: 542.6: 572.8: 4: 798.8: 654.0: 952.8: 853.6: 5: 11612: 965.0: 14010: 1096.0: 6 . Based on sample size the charts above represents ~68% of the population. Originated in 1925 by Robert W. Dawley from a hybrid hooded male and a female Wistar rat. A main study starting dose of 5,000 mg/kg was the limit in the acute toxicity study. grams) ENVIGO . Ten rats from each of two colonies, a low-D Holtzman colony (Madison, WI, U.S.A.) and a supp-D Sprague Dawley colony (Indianapolis, IN, U.S.A.), were sacrificed upon arrival from the breeder. In 2004 Envigo acquired RCC Ltd. and new breeding stock was transferred in 2008 (nomenclature RccHan :WIST). At day 14 of gestation, rats destined for reduced uterine perfusion were clipped as described below. . All rats were divided into four groups; group O (not given alendronate); group A (subcutaneous injection) 24 Sprague Dawley female mice that have given birth, weighing 200 grams aged 5 months. Week 0 BW was slightly lower in the InT-controls and higher in CsX-DRT compared to the other five experimental groups; however, BW increased similarly in all groups over . We found that reducing the correlation between sweet taste and the caloric content of foods using artificial sweeteners in rats resulted in increased . The tumors . Sprague-Dawley rats were received from Charles River Breeding Laboratories, Inc., and were individually housed in stainless steel cages with feed (Purina Laboratory . A total of 40 adult male specific-pathogen free (SPF) Sprague Dawley rats (Rattus norvegicus, age range from 7 weeks to 8 weeks, weighing 250-300 g) obtained from the animal center of Southern Medical University (certificate number: SYXK [Yue] 2011-0074), were housed in a . Origin: The Sprague Dawley outbred model was developed by Sprague Dawley, Inc. NIH received stock from Sprague Dawley, Inc in 1945. 3.2. Established in 1925 by Robert Dawley, the original Sprague Dawley rat colony was obtained by Harlan in 1980 through the acquisition of Sprague-Dawley, Inc. Harlan became Envigo in 2015. Reference values for young normal Sprague-Dawley rats: weight gain, hematology and clinical chemistry 1. . Their average lifespan is 2 - 3 years making them excellent candidates for long-term studies. . Additional charges will apply. 28: C57BL/6J mice: Increased (no raw data) Increased (no raw data . Hsd:Sprague Dawley SD Production Facility 505-B4, Horst - NL (2012) . 11 were conducted in rats (8 in Sprague-Dawley rats, 2 in Wistar rats, 1 study in Brown Norway rats), whereas the remaining studies were conducted in mice (3 in C57BL6, 4 in . All the default values listed in the table including body weight, food intake and water intake, are obtained from U.S. EPA (1988) and based . May have small weight loss. More inflammation vs. HFD. The increase in weight was greater in ApoE KO on a Western diet and there was a significant difference in body weight between this group and ApoE KO and Sprague Dawley rats on a standard diet (P . Level of . Figure 2 Adrenal gland, Cortex - Hypertrophy in a female Sprague-Dawley rat from a chronic study (higher magnification of Figure 1).
In a 2-year dermal carcinogenicity study, naftifine hydrochloride cream was administered to Sprague-Dawley rats at topical doses of 1%, 2% and 3% (10, 20, and 30 mg/kg/day naftifine hydrochloride). Sprague-Dawley 0.204 0.031 0.152 0.020 0.098 0.338 0.045 0.133 0.027 0.080 0.056 0.012 0.214 0.008 0.148 Wistar 0.156 0.025 0.160 0.016 0.103 0.297 0.041 0.138 0.025 0.084 0.052 0.011 0.212 0.008 0.154 .
Other variables such as femur ash weight and calcium content were also highly correlated to densities with both techniques. . multiple metabolic pathways in normal Sprague-Dawley rats. The study formed part of a unilateral surgical salpingectomy trial with 16 female Sprague-Dawley rats (Rattus norvegicus). Hepatic. Bar chart showing weight of right kidney in male sprague-dawley rats. The cells in this focus of hypertrophy (FH) have increased amounts of pale eosinophilic cytoplasm. Growth chart includes mean 2 SD's representative of population distribution. Data can be subject to differences in maintenance of rats. Fifteen female Sprague-Dawley rats (mean weight 246.5 13.1g) bred in-house were used. Body weight and metabolic parameters were determined. but the optimal diet to achieve weight loss and (AI) was used as the markers of vascular . Hepatic and peripheral. The chart below indicates specific parameters that are monitored . 83 1 days; P 0.05) and weight (HSD 341 7 g; CRSD 373 8g;P 0.05) of HSD and CRSD rats at the time of electrophysio- . Data are presented as mean SEM (n = 6 rats per group). The female rats were randomly divided into control and treatment groups of five rats each. Our objec- Thirty-one male Sprague Dawley rats, 22 days of age, were purchased from Harlan Sprague-Dawley (Indianapolis, IN). Growth Curve Of Female Sprague Dawley Rats Given 4 Hydroxytamoxifen By Scientific Diagram. zation and Standardization of Male Gonad Weight Determinations in Rats. Downloaded from tpx.sagepub.com at SAGE PUBLICATIONS on December 9, 2012. The wild-type Sprague Dawley rat thymus was comprised mostly of CD4/CD8 double positive cells . Growth chart includes mean 2 SD's representative of population . Mild-TBI was performed by the weight-drop method in male Sprague-Dawley rats. In 1991, 8 colonies were selected to form the IGS Foundation Colony. The evaluation of 393 studies, including 404 individual animal experiments, led to the identification of the following animal models: (1) transection at T10 in female Sprague-Dawley rats, (2) hemisection at T10 in male Sprague-Dawley rats, (3) contusion at T10 in female Sprague-Dawley rats, and (4) compression at T9 in female Sprague . Chart 7.0; ADInstruments). Environmental Factor Newsletter. . Exp. (Syazana et al., 2011) This study aimed to evaluate the effect of Tualang Honey on the reproductive system in male Sprague Dawley Rats with the age of 8 weeks and weight of 200 to 230 gm based on time dependent. Data can be subject to differences in maintenance of rats. Maternal High-Salt Diet During Pregnancy in Sprague Dawley Rats . We obtained two sublines of Sprague-Dawley (SD) rats by a strict inbreeding process: one with a high-yawning frequency (HY) of 20 yawns/h, which is one order of magnitude higher with . vasculogenesis (61% and 98%) when treated with MSC Disease (CR) and DM 2 were studied by retrospective chart review in VA or MSC pre-stimulated with exogenous EGF, respectively. water available ad libitum. Bioz Stars score: 86/100, based on 1 PubMed citations. Adolescents were shown to gain an average of 4.1 g/daya rate of gain that cumulatively resulted in body weights at the end of the experiment that were approximately 83.5% of what same aged, free-feeding Sprague-Dawley female rats would have weighed at that age. Adult male Sprague-Dawley rats were given differential experience with a sweet taste that either predicted increased caloric content (glucose) or did not predict increased calories (saccharin). The Sprague Dawley outbred model was developed by Sprague Dawley, Inc. NIH received stock from Sprague Dawley, Inc in 1945. . Harlan became Envigo in 2015. Estrous cycle was monitored by vagina smear technique, weekly weight recorded, and serum collected at the end of treatment period. The SPRAGUE DAWLEY rat aka SD, is an albino outbred rat with an elongated head and a tail that is longer than its body. The strain was created by R. W. Dawley in 1925, from a hooded male hybrid of unknown origin and an albino female (probably Wistar), and was crossed with the female's progeny for 7 generations.